微生物生理与代谢调控研究室
Laboratory of Microbial Physiology and Metabolic Regulation
国家自然科学基金
1. 大肠杆菌全局性转录因子CRP在代谢压力下调控细胞适 应性机制研究（21878198），主持人：王崇龙
2. 糖转运蛋白在普鲁兰高效合成中的调控作用及生理机制（21776189），主持人：卫功元
3. 酸胁迫提升产朊假丝酵母富硒能力的分子机制（21506136），主持人：王大慧
4. 基于能量代谢调控的SAM和GSH联合高产机制研究（21376155），主持人：卫功元
5. 谷胱甘肽在假丝酵母抵抗酸胁迫中的作用机制（20906065），主持人：卫功元
中韩国际合作项目
1. 基于合成生物学的萜类物质高效生产元件的开发（PJ00903002），主持人：王崇龙
江苏省自然科学基金
1. 基于UDPG代谢调控的普鲁兰高效合成机制解析（BK20181440），主持人：王大慧
苏州市农业应用基础研究项目
1. 基于转录组测序分析的高性能富硒产朊假丝酵母制备及其在提高雏鸡免疫功能中的作用（ SNG201606），主持人：卫功元
2. 基于酸胁迫的富硒/GSH酵母高效制备及其在雏鸡饲养中的应用（SYN201314 ），主持人：王大慧
3. 基于生物合成的类胡萝卜素对中华绒螯蟹色素沉积和免疫调控的机制及其应用研究（SYN2019**），主持人：王崇龙
代表性研究论文
[1] Da-Hui Wang, Teng-Fei Ni, Xiao-Min Ju, Gong-Yuan Wei. Sodium chloride improves pullulan production by Aureobasidium pullulans but reduces the molecular weight of pullulan. Applied Microbiology and Biotechnology, 2018, 102: 8921-8930.
[2] Wang Chonglong, Zada Bakht, Park Ji-Bin, Jeong Seong-Hee, Park Ju-Eon, Singh Hawaibam Birlia, Kim Seon-Won. Metabolic engineering of Escherichia coli for production of mixed isoprenoid alcohols and their derivatives. Biotechnology for Biofuels, 2018, 11: 210.
[3] Zhang Gaochuan, Wang Dahui, Wang Donghua, Wei Gongyuan. The mechanism of improved intracellular organic selenium and glutathione contents in selenium-enriched Candida utilis by acid stress. Applied Microbiology and Biotechnology, 2017, 101(5): 2131-2141.
[4] Wang Chonglong, pfleger Brian F, Kim Seon-Won. Reassessing Escherichia coli as a cell factory for biofuel production. Current Opinion in Biotechnology, 2017, 45: 92-103.
[5] Dahui Wang, Xiaomin Ju, Gaochuan Zhang, Donghua Wang, Gongyuan Wei. Copper sulfate improves pullulan production by bioconversion using whole cells of Aureobasidium pullulans as the catalyst. Carbohydrate Polymer, 2016, 150: 209-215.
[6] Xiao-Min Ju, Da-Hui Wang, Gao-Chuan Zhang, Dan Cao, Gong-Yuan Wei. Efficient pullulan production by bioconversion using Aureobasidium pullulans as the whole-cell catalyst. Applied Microbiology and Biotechnology, 2015, 99(1): 211-220.
[7] Wang Dahui, Ju Xiaomin, Zhou Donghai, Wei Gongyuan. Efficient production of pullulan using rice hull hydrolysate by adaptive laboratory evolution of Aureobasidium pullulans. Bioresource Technology, 2014, 164: 12-19.
[8] Wang Chonglong, Zhou Jia, Jang Hui-Jeong, Yoon Sang-Hwal, Kim Jae-Yean, Lee Seung-Goo, Choi Eui-Sung, Kim Seon-Won. Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli. Metabolic Engineering, 2013, 18: 53-59.